COMPARING SEVEN MITOGENS WITH PHA-M FOR IMPROVED LYMPHOCYTE STIMULATION IN DICENTRIC CHROMOSOME ANALYSIS FOR BIODOSIMETRY
نویسندگان
چکیده
منابع مشابه
PHA stimulation may be useful for FDXR gene expression-based biodosimetry
Objective(s): Nowadays, ionizing radiation (IR) has a significant contribution to the diagnostic and therapeutic medicine, and following that, health risks to individuals through unexpected exposure is greatly increased. Therefore, biological and molecular technology for estimation of dose (biodosimetry) is taken into consideration. In biodosimetry methods stimulation ...
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We present a prototype software system with sufficient capacity and speed to estimate radiation exposures in a mass casualty event by counting dicentric chromosomes (DCs) in metaphase cells from many individuals. Top-ranked metaphase cell images are segmented by classifying and defining chromosomes with an active contour gradient vector field (GVF) and by determining centromere locations along ...
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Accurate digital image analysis of abnormal microscopic structures relies on high quality images and on minimizing the rates of false positive (FP) and negative objects in images. Cytogenetic biodosimetry detects dicentric chromosomes (DCs) that arise from exposure to ionizing radiation, and determines radiation dose received based on DC frequency. Improvements in automated DC recognition incre...
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Biological radiation dose can be estimated from dicentric chromosome frequencies in metaphase cells. Performing these cytogenetic dicentric chromosome assays is traditionally a manual, labor-intensive process not well suited to handle the volume of samples which may require examination in the wake of a mass casualty event. Automated Dicentric Chromosome Identifier and Dose Estimator (ADCI) soft...
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ژورنال
عنوان ژورنال: Radiation Protection Dosimetry
سال: 2015
ISSN: 0144-8420,1742-3406
DOI: 10.1093/rpd/ncv286